INTEGRATING MACHINE LEARNING MODELS WITH MULTI-OMICS ANALYSIS TO DECIPHER THE PROGNOSTIC SIGNIFICANCE OF MITOTIC CATASTROPHE HETEROGENEITY IN BLADDER CANCER

Abstract Background Mitotic catastrophe is well-known as a major pathway of endogenous tumor death, but the prognostic significance of its heterogeneity regarding bladder cancer (BLCA) remains unclear.Methods Our study focused on digging deeper into the TCGA and GEO databases.Through differential expression analysis as well as Weighted Gene Co-expr

This paper introduces a novel Improved Dwarf Mongoose Optimizer (IDMO) based on an Alpha-Directed Learning Process (ADLP) for dealing with different mathematical benchmark models and engineering problems.The dwarf mongoose’s foraging behavior motivated the DMO’s primary design.Three social groupings are used: the alpha group, babysitt

Severe acute respiratory syndrome Carpet Cleaning Equipment coronavirus 2 (SARS-CoV-2) virus is the cause of the current global pandemic and has affected more than 188 countries worldwide.Infection by the virus can have diverse clinical manifestations, with one of the most severe clinical manifestation being respiratory failure and the development

DNA copies of many non-retroviral RNA virus genes or portions thereof (NIRVs) are present in the nuclear genomes of many eukaryotes.These have often been preserved for millions of years Mobility of evolution, suggesting that they play an important cellular function.One possible function is resistance to infection by related viruses.In some cases, t

Hexokinase (HK) catalyzes the first irreversible rate-limiting step in glycolysis that converts glucose to glucose-6-phosphate.HK1 is ubiquitously expressed in the brain, erythrocytes, and other tissues where glycolysis serves as the major source of ATP production.Spermatogenic cell-specific type 1 hexokinase (HK1S) is expressed in sperm but its ph